1500s

A list of events in the 1500s, otherwise known as the Sixteenth Century, related to Pirates of the Caribbean.

1513

 * Unknown date – Juan Ponce de León became the first European to discover Florida.

1519

 * Unknown date – Hernán Cortés conquered Mexico and the Aztec Empire. Note: According to the Jack Sparrow series, Cortés was able to conquer the Aztecs through the use of the Sword of Cortés.

1521

 * Unknown date – Juan Ponce de León died. Note: In real-world history, Ponce de León died on Cuba because of a wound from a poisoned arrow. But according to promotional material for Pirates of the Caribbean: On Stranger Tides, Ponce de León died aboard the Santiago during his search for the Fountain of Youth.

1547

 * December 2 – Hernán Cortés died.

Unknown dates

 * The Santiago, captained by Ponce de León was sent to discover the marvels of the New World. At some point, the Santiago disappeared during Ponce de León's search for the Fountain of Youth in 1523.