- "I love this song! Really bad eggs! When I get the Pearl back, I'm gonna teach it to the whole crew, and we'll sing it all the time."
"And you'll be positively the most fearsome pirate in the Spanish Main."
"Not just the Spanish Main, love. The entire ocean. The entire world."
- ―Jack Sparrow and Elizabeth Swann
From the 16th century through the 18th century, the Spanish Main was the point of departure for enormous wealth that was shipped back to Spain in the form of gold, silver, gems, spices, hardwoods, hides and other riches. Silver in the form of pieces of eight was brought to the Spanish Main by llama and mule train from Potosí via the Pacific coast, while wares from the Far East that had arrived at Acapulco on the Manila galleons were also then transported overland to the Spanish Main. From there they were shipped to Spain by Spanish galleons. Due to the tremendous riches which were shipped from it, the Spanish Main was ripe territory for pirates and privateers.
The Spanish Pirate Lord Eduardo Villanueva occasionally boasted that his galleon, the Centurion, was the best ship on the Spanish Main. While marooned on Rumrunner's Isle, Elizabeth Swann and Jack Sparrow talked about Jack being the most fearsome pirate in the Spanish Main, though Jack aimed for the entire ocean and the entire world. During the quest for the Fountain of Youth, the HMS Providence, among other ships involved in the quest, sailed on course for the Spanish Main in their voyage.
- The Price of Freedom
- Legends of the Brethren Court: Day of the Shadow (Mentioned only)
- Pirates of the Caribbean: The Curse of the Black Pearl (First appearance)