Stone-Eyed Sam was a pirate captain and ruler of the so-called City of the Dead on Isla Esquelética. He hid a cache of treasure on the island, later uncovered by Captain Jack Sparrow and the crew of the Barnacle.
- "Sorry, mate, but you can't be Stone-Eyed Sam. He's dead."
- ―Jack Sparrow to Stone-Eyed Sam
While Jack and Fitzwilliam P. Dalton III were traveling through time with the Timekeeper, they were brought before Stone-Eyed Sam. Later, Stone-Eyed Sam touched and released the Timekeeper during a battle, restoring order to time.